Endoplasmic reticulum stress-driven nucleotide catabolism fuels prostate cancer

New Publication from Our Group!

We’re excited to share our latest research published in Cancer Letters under the title: “Endoplasmic reticulum stress-driven nucleotide catabolism fuels prostate cancer”

In this study, we uncover how ER stress signaling pathways—specifically ATF4 and XBP1s—play a central role in regulating purine metabolism in prostate cancer. Key findings include:

• ATF4 and XBP1s drive purine catabolism by upregulating MOCOS and XDH, respectively.
• Loss of MOCOS disrupts nucleotide balance and triggers replication stress.
• Targeting XDH mimics these effects and significantly impairs cancer cell growth.

This work highlights a previously underappreciated connection between ER stress and nucleotide metabolism, revealing potential new targets for prostate cancer therapy.

Congratulations to all authors on this important contribution!